Triplet combinations containing a proteasome inhibitor are a typical of care in newly identified a number of myeloma (NDMM). Previously, Sahpra had granted Section 21 access, on a restricted basis, to generics of excessive-priced patented drugs obtainable in South Africa on the premise that medicines had been priced out of attain for sufferers knocking at death's door.
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Continuous lenalidomide plus low-dose dexamethasone till progression confirmed improved PFS compared with MPT and Rd18 (25.5 vs 21.2 versus 20.7 months; Rd vs MPT, p = 0.00006) and improved 4-year OS compared with MPT (59.four% vs fifty one.4%, p = zero.0168).
In patients with newly diagnosed transplant-ineligible a number of myeloma, continuous lenalidomide-dexamethasone was superior to melphalan, prednisone, and thalidomide (MPT) (72 weeks) for all primary and secondary efficacy endpoints, including OS, at the time of ultimate analysis of major endpoint, PFS.
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